Many years-Outdated Soviet Research Trace at Coronavirus Technique

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Decades-Old Soviet Studies Hint at Coronavirus Strategy

MOSCOW — To the boys, it was just a sugary treat. To their parents, prominent medical researchers, what happened in their Moscow apartment that day in 1959 was a vital experiment with countless lives at stake — and their own children as guinea pigs.

“We formed a kind of line,” Dr. Peter Chumakov, who was 7 at the time, recalled in an interview. Into each waiting mouth, a parent popped a sugar cube laced with weakened poliovirus — an early vaccine against a dreaded disease. “I was eating it from the hands of my mother.”

Today, that same vaccine is gaining renewed attention from researchers — including those brothers, who all grew up to be virologists — as a possible weapon against the new coronavirus, based in part on research done by their mother, Dr. Marina Voroshilova.

Dr. Voroshilova established that the live polio vaccine had an unexpected benefit that, it turns out, could be relevant to the current pandemic: People who got the vaccine did not become sick with other viral illnesses for a month or so afterward. She took to giving the boys polio vaccine each fall, as protection against flu.

Now, some scientists in several countries are taking a keen interest in the idea of repurposing existing vaccines, like the one with live poliovirus and another for tuberculosis, to see if they can provide at least temporary resistance to the coronavirus. Russians are among them, drawing on a long history of vaccine research — and of researchers, unconcerned about being scoffed at as mad scientists, experimenting on themselves.

Experts advise that the idea — like many other proposed ways of attacking the pandemic — must be approached with great caution.

“We are much better off with a vaccine that induces specific immunity,” Dr. Paul A. Offit, a co-inventor of a vaccine against the rotavirus and professor at the Perelman School of Medicine at the University of Pennsylvania, said in a telephone interview. Any benefits from a repurposed vaccine, he said, are “much shorter lived and incomplete,” compared with a tailored vaccine.

Still, Dr. Robert Gallo, a leading advocate of testing the polio vaccine against coronavirus, said that repurposing vaccines is “one of the hottest areas of immunology.” Dr. Gallo, director of the Institute of Human Virology at the University of Maryland School of Medicine, said that even if the weakened poliovirus confers immunity for only a month or so, “it gets you over the hump, and it would save a lot of lives.”

But there are risks.

Billions of people have taken live poliovirus vaccine, nearly eradicating the disease. However, in extremely rare cases, the weakened virus used in the vaccine can mutate into a more dangerous form, cause polio and infect other people. The risk of paralysis is estimated at one in 2.7 million vaccinations.

For those reasons, public health organizations say that once a region eliminates naturally occurring polio, it must stop routine use of oral vaccine, as the United States did 20 years ago.

And this month, the National Institute of Allergy and Infectious Diseases delayed a study designed by Dr. Gallo’s institute, the Cleveland Clinic, the University of Buffalo and Roswell Park Comprehensive Cancer Center to test the effectiveness of live polio vaccine against coronavirus, using health care workers as subjects. The agency raised safety concerns, including the chance of live poliovirus making its way into water supplies and infecting others, according to researchers familiar with the study application. The press office of the N.I.A.I.D. declined to comment.

But other countries are moving ahead. Trials with the polio vaccine have begun in Russia, and are planned in Iran and Guinea-Bissau.

A specific vaccine for the coronavirus would be one that trains the immune system to target that virus specifically, and more than 125 vaccine candidates are under development around the world.

Repurposed vaccines, in contrast, use live but weakened viruses or bacteria to stimulate the innate immune system more broadly to fight pathogens, at least temporarily.

The first polio vaccine, developed by Dr. Jonas Salk, an American, used “inactivated” virus — particles of killed virus. It had to be injected, an obstacle to immunization campaigns in poorer countries.

When that vaccine was widely introduced in 1955, Dr. Albert Sabin was testing a vaccine using live but attenuated poliovirus, which could be taken orally. But in the United States, with the Salk vaccine already in use, the authorities were reluctant to take the perceived risk of conducting live-virus trials.

Dr. Sabin gave his three strains of attenuated virus to a married pair of virologists in the Soviet Union, Dr. Mikhail Chumakov, the founder of a polio research institute that now bears his name, and Dr. Voroshilova.

Dr. Chumakov vaccinated himself, but a medicine intended primarily for children needed child test subjects, so he and Dr. Voroshilova gave it to their three sons and several nieces and nephews.

Their experiment enabled Dr. Chumakov to persuade a senior Soviet official, Anastas Mikoyan, to proceed with wider trials, eventually leading to the mass production of an oral polio vaccine used around the world. The United States began oral polio vaccinations in 1961 after it was proved safe in the Soviet Union.

“Somebody has to be the first,” Dr. Peter Chumakov said in an interview. “I was never angry. I think it was very good to have such a father, who is confident enough that what he is doing is right and is sure he will not harm his children.”

His mother was, if anything, even more enthusiastic about running the tests on the boys, he said.

“She was absolutely sure there was nothing to be scared of,” he said.

Something Dr. Voroshilova noticed decades ago has renewed interest in the oral vaccine.

A typical healthy child is host to a dozen or so respiratory viruses that cause little or no illness. But Dr. Voroshilova could not find any of them in children soon after they were immunized against polio.

  • Updated June 24, 2020

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      A commentary published this month on the website of the British Journal of Sports Medicine points out that covering your face during exercise “comes with issues of potential breathing restriction and discomfort” and requires “balancing benefits versus possible adverse events.” Masks do alter exercise, says Cedric X. Bryant, the president and chief science officer of the American Council on Exercise, a nonprofit organization that funds exercise research and certifies fitness professionals. “In my personal experience,” he says, “heart rates are higher at the same relative intensity when you wear a mask.” Some people also could experience lightheadedness during familiar workouts while masked, says Len Kravitz, a professor of exercise science at the University of New Mexico.

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      So far, the evidence seems to show it does. A widely cited paper published in April suggests that people are most infectious about two days before the onset of coronavirus symptoms and estimated that 44 percent of new infections were a result of transmission from people who were not yet showing symptoms. Recently, a top expert at the World Health Organization stated that transmission of the coronavirus by people who did not have symptoms was “very rare,” but she later walked back that statement.

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A huge study in the Soviet Union of 320,000 people, from 1968 to 1975, overseen by Dr. Voroshilova, found reduced mortality from flu in people immunized with other vaccines, including the oral polio vaccine.

She won recognition in the Soviet Union for demonstrating a link between vaccinations and broad protection against viral diseases, likely by stimulating the immune system.

Dr. Voroshilova’s and Dr. Chumakov’s work clearly influenced their sons’ minds as well as their health — not only did all of them become virologists, they embraced self-testing as well.

Dr. Peter Chumakov today is the chief scientist at the Engelhardt Institute of Molecular Biology at the Russian Academy of Sciences and co-founder of a company in Cleveland that treats cancer with viruses. He has developed about 25 viruses for use against tumors — all of which, he said, he has tested on himself.

He is also now taking polio vaccine, which he grows in his own laboratory, as possible protection against coronavirus.

Dr. Ilia Chumakov, a molecular biologist, helped sequence the human genome in France.

Dr. Alexei Chumakov, who was not yet born when his parents experimented on his brothers, worked as a cancer researcher at Cedars-Sinai in Los Angeles for much of his career. While working in Moscow, he developed a vaccine against hepatitis E, which he tested first on himself.

“It’s an old tradition,” he said. “The engineer should stand under the bridge when the first heavy load goes over.”

Dr. Konstantin Chumakov is an associate director of the U.S. Food and Drug Administration’s Office of Vaccine Research and Review, which would be involved in approving any coronavirus vaccines for use in Americans. He is also a co-author, with Dr. Gallo and others, of a recent article in the journal Science that promotes research into repurposing existing vaccines.

In an interview, Dr. Konstantin Chumakov said he cannot remember eating the sugar cube back in 1959 — he was 5 years old — but approved of his parents’ experiment as a step toward saving untold numbers of children from paralysis.

“It was the right thing to do,” he said. “Now, there would be questions, like ‘Did you get permission from the ethics committee?’”

Oleg Matsnev contributed reporting from Moscow.

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